Synovial mesenchymal stem cells promote the meniscus repair in a novel pig meniscus injury model
نویسندگان
چکیده
منابع مشابه
Mesenchymal Stem Cells in Synovial Fluid Increase After Meniscus Injury
BACKGROUND Although relatively uncommon, spontaneous healing from a meniscus injury has been observed even within the avascular area. This may be the result of the existence of mesenchymal stem cells in synovial fluid. QUESTIONS/PURPOSES The purpose of this study was to investigate whether mesenchymal stem cells existed in the synovial fluid of the knee after meniscus injury. METHODS Synovi...
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Although meniscus defects and degeneration are strongly correlated with the later development of osteoarthritis, the promise of regenerative medicine strategies is to prevent and/or delay the disease's progression. Meniscal reconstruction has been shown in animal models with tendon grafting and transplantation of mesenchymal stem cells (MSCs); however, these procedures have not shown the same e...
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Background: The meniscus is a semilunar fibro-cartilaginous tissue performing various function including knee joint stability, shock absorption, load distribution, joint lubrication, and joint congruity. Menisectomy often leads to articular cartilage degeneration and ends up in osteoarthritis of knee. Authors described use of mesenchymal stem cells for evaluation of healing of meniscus tear. Pu...
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Controversy remains whether articular cartilage has an endogenous stem/progenitor cell population, since its poor healing capacity after injury can lead to diseases such as osteoarthritis. In the joint environment there are mesenchymal stem/progenitor cells (MSCs) in the synovial membrane and synovial fluid that can differentiate into cartilage, but it is still under debate if these cells contr...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Research
سال: 2020
ISSN: 0736-0266,1554-527X
DOI: 10.1002/jor.24846